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BIOM 503
LECTURE ASSIGNMENT 4 INSTRUCTIONS
Compose a paragraph-style response for the essay topics listed below. The assignment must
reflect your own understanding of the course material.
1. Describe the function of the PAZ and RNase III domains within the Dicer enzyme.
Compare and contrast those with the function of the PAZ and PIWI domains of the
Argonaute enzyme.
2. What is the function of DGCR8?
3. Based on “Origins and Mechanisms of miRNAs and siRNAs,” describe 1 of the 5 modes
by which miRNAs can inhibit translation.
4. Based on “MicroRNAs control de novo DNA Methylation through Regulation of
Transcriptional repressors in Mouse Embryonic Stem Cells,” what observations made
Rbl2 a likely candidate for the miR-290 regulated repressor of Dnmt3a2, Dnmt3b, and
Dnmt3L?
5. Based on the regulation of Dnmt3a and Dnmt1, state how the following conditions might
alter the levels of these proteins.
a) The loss of Dicer activity (i.e., cells become Dicer-/-)
b) Overexpression of Rbl2
c) Loss of expression from the miR-290 cluster
Submit your assignment by 11:59 p.m. (ET) on Sunday of Module/Week 2.
Note: Be sure to label each answer by its number. Ensure that all answers to the questions are
detailed.

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